TrueConsense

TrueConsense is a nucleotide consensus caller capable of creating a biologically valid consensus-sequence in reference-based virus sequencing experiments.

TrueConsense is, in contrast to more common consensus-sequence methodology, not using VCF files. Instead, a consensus-sequence is made directly from a BAM-file in order to get a proper view of positional context.

TrueConsense compensates for common sequencing and/or alignment artefacts and keeps track of open reading frames in order to create a biologically valid viral consensus-sequence.

TrueConsense is available under the AGPLv3 licence